Sedating antihistamines mechanism of action
Sedatives are a diverse group of drugs manufactured for medical purposes to relax the central nervous system.Also known as tranquillizers or central nervous system (CNS) depressants, they encompass drug classes such as barbiturates, benzodiazepines, non-benzodiazepine sedative-hypnotics, anesthetics, antihistamines and opioid narcotics, as well as herbal compounds.The effects of the sedatives tend to be dose dependent, and often the only difference between anxiolytic and hypnotic effect is the dose.Consequently, the same drug can be used for both purposes just by varying the dose.Steven Lazer Digital pathology is the viewing, analyzing, and managing of digitalized pathology slides with computer technology called whole slide imaging, or WSI, which generates a tremendous volume of data.A single whole slide image can be a gigabyte or larger in size.
Sedatives are usually classified according to the way they affect the human body.
Because of their toxicity, bromides were replaced by barbiturates in the early 20th century, which were initially also heralded as effective and safe sedative drugs.
However, in a short period of time problems with dependence, tolerance and lethal overdosing became evident.
Although initially viewed as completely safe and free from problems of dependence, tolerance and withdrawal, today we know that benzodiazepines are less than ideal antianxiety drugs, and that their long-term usage can cause all the aforementioned effects associated with their sedative predecessors.
During the 1970s and 1980s, there was an epidemic of prescriptions written for sedatives (for example, 100 million prescriptions were written for benzodiazepines alone in 1973).
As the margin of safety for barbiturates was too narrow, research endeavors for safer sedatives continued.